I am a Neuroscience Researcher at CSIR-Centre for Cellular and Molecular Biology (CCMB) specializing in CNS axon regeneration. My research focuses on understanding the Epigenetic mechanisms of neural repair and regeneration after injury.
My work combines advanced imaging techniques, single-cell genomics, molecular biology, Animal surgeries and behavioral assessment to develop a comprehensive understanding of neural regeneration processes in adult mouse model organisms. I'm particularly interested in identifying and targeting the intrinsic barriers that could inhibit recovery after spinal cord injury.
When I'm not in the lab, I enjoy science communication and mentoring young researchers interested in neuroscience. I believe in making complex scientific concepts accessible to broader audiences.
Our lab focuses on understanding the cellular and molecular mechanisms that control axon regeneration after injury.
Our lab focuses on molecular mechanisms that can effectively promote central nervous system axon regeneration following injury. I investigate the key transcriptional machinery that activates intrinsic regenerative potential, enabling axons in the spinal cord to grow beyond injury sites.
Understanding the link between chromatin accessibility and the regeneration ability of Central Nervous System axons.
We investigates how chromatin accessibility restricts the regeneration potential of central nervous system neurons. To study chromatin remodeling, we use snATAC sequencing techniques and Cut and Run sequencing to analyze histone marks and modifications.
Exploring how three-dimensional organization changes upon Central Nervous System axon injury.
We investigate how the three-dimensional organization of the genome changes upon CNS injury and how we can effectively modulate these changes to promote axon growth and regeneration. Using advanced techniques like Hi-C, we analyze chromosomal interactions within the genome.
Proficient in techniques such as qPCR, cloning, Western blotting, and immunohistochemistry to investigate molecular mechanisms of neural regeneration.
Expertise in spinal cord injury models, Stereotaxic Injections, and behavioral assessment methodologies to evaluate recovery after CNS injury.
Experience with single-cell RNA, ATAC, Cut & Run, Hi-C sequencing to identify cell-type specific responses to injury and potential therapeutic targets.
Skilled in primary neuron cultures, maintenance of neural cell lines, and in vitro models of axon growth and regeneration.
Trained in confocal microscopy to assess spinal cord regeneration and brain signals. Expertise in fluorescence imaging and 3D reconstruction of neural tissues.
Computational analysis of genomic data, pathway analysis, and visualization of complex datasets related to neural regeneration.
Using genome-wide chromatin conformation capture (Hi-C), we map how the three-dimensional architecture of the genome is reorganised in adult CNS neurons and show that this spatial rewiring encodes their intrinsic capacity to regenerate axons after injury.
View PreprintA machine-learning framework for precise, automated measurement of neurite outgrowth, enabling high-throughput and reproducible quantification of neuronal growth from microscopy images.
View PreprintWe show that PATZ1 remodels the nucleosome landscape in injured neurons, increasing chromatin accessibility at growth-associated loci to support a regeneration-permissive state.
View PreprintWe identify nuclear receptor transcription factors that promote axon regeneration in the adult corticospinal tract, highlighting transcriptional programmes that can reactivate growth in CNS neurons.
View PreprintWe discovered how chromatin becomes restrictive in CNS neurons during development and demonstrated that PATZ1 can reopen this restricted chromatin to promote neural regeneration after injury, revealing why adult neurons lose their growth capacity and a potential therapeutic target for spinal cord injury.
View PreprintRecognised for poster presentation on epigenetic and three-dimensional genome mechanisms underlying axon regeneration in the central nervous system.
Awarded for research on targeted epigenetic mechanisms in CNS axon repair following injury.
Recognized for Best Poster presentation on Neuroscience Conference
Download my complete CV for a detailed overview of my academic background, research experience, and achievements.
Email: anisha@ccmb.res.in
Lab: Dr Ishwariya Venkatesh, Venkatesh Lab CSIR-CCMB
Address:
Centre for Cellular and Molecular Biology (CSIR-CCMB)
Habsiguda, Hyderabad
Telangana 500007, India
Feel free to reach out regarding research collaborations, speaking engagements, or questions about my work. I'm always open to discussing new ideas and potential partnerships.
